Comparative Evaluation of Mitochondrial Antioxidants in Oral Potentially Malignant Disorders.
Identifieur interne : 000085 ( Main/Exploration ); précédent : 000084; suivant : 000086Comparative Evaluation of Mitochondrial Antioxidants in Oral Potentially Malignant Disorders.
Auteurs : Sumita Banerjee ; Saikat Mukherjee ; Sanjib Mitra ; Pallav SinghalSource :
- The Kurume medical journal [ 1881-2090 ] ; 2020.
Abstract
Various endogenous mitochondria-associated antioxidants protect mitochondria from oxidative stresses such as Superoxide Dismutase 2 (SOD2), Catalase, Glutaredoxin 2 (GLRX2), educed Glutathione (GSH), Glutathione Peroxidase (GPx), and Thioredoxin 2 (TXN2). They protect mitochondria from Reactive Oxygen Species (ROS). Excess ROS causes mitochondrial DNA damage and respiratory chain dysfunction leading to carcinogenesis. In an earlier study we found complex alterations of mitochondrial antioxidants in different stages of oral squamous cell carcinoma. Here, we profiled mitochondrial antioxidants in different oral potentially malignant disorders such as oral leukoplakia (OL), oral lichen planus (OLP), and oral submucous fibrosis (OSMF). Mitochondria was prepared from oral tissues from OL, OLP, and OSMF patients. Biochemical assays and immunoblotting were performed to investigate expression of various mitochondrial antioxidants. Catalase was expressed as Control> OL > OSMF > OLP. GLRX 2 was expressed as OLP> OL >Control >OSMF. GPX1 and GPX4 were expressed as Control >OSMF> OLP > OL. GSH increased in OL and OSMP, but decreased in OLP. SOD2 was expressed as Control >OSMF> OLP > OL. PRX3 was expressed as OL > OLP > OSMF > Control. TXN2 expression was nearly the same in all groups except OL, which showed elevated expression. We conclude that endogenous mitochondria-associated antioxidants show different levels of expressions in various oral potentially malignant disorders.
DOI: 10.2739/kurumemedj.MS661009
PubMed: 32378537
Affiliations:
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They protect mitochondria from Reactive Oxygen Species (ROS). Excess ROS causes mitochondrial DNA damage and respiratory chain dysfunction leading to carcinogenesis. In an earlier study we found complex alterations of mitochondrial antioxidants in different stages of oral squamous cell carcinoma. Here, we profiled mitochondrial antioxidants in different oral potentially malignant disorders such as oral leukoplakia (OL), oral lichen planus (OLP), and oral submucous fibrosis (OSMF). Mitochondria was prepared from oral tissues from OL, OLP, and OSMF patients. Biochemical assays and immunoblotting were performed to investigate expression of various mitochondrial antioxidants. Catalase was expressed as Control> OL > OSMF > OLP. GLRX 2 was expressed as OLP> OL >Control >OSMF. GPX1 and GPX4 were expressed as Control >OSMF> OLP > OL. GSH increased in OL and OSMP, but decreased in OLP. SOD2 was expressed as Control >OSMF> OLP > OL. PRX3 was expressed as OL > OLP > OSMF > Control. TXN2 expression was nearly the same in all groups except OL, which showed elevated expression. We conclude that endogenous mitochondria-associated antioxidants show different levels of expressions in various oral potentially malignant disorders.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32378537</PMID><DateRevised><Year>2020</Year><Month>07</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1881-2090</ISSN><JournalIssue CitedMedium="Internet"><Volume>66</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>Jul</Month><Day>01</Day></PubDate></JournalIssue><Title>The Kurume medical journal</Title><ISOAbbreviation>Kurume Med J</ISOAbbreviation></Journal><ArticleTitle>Comparative Evaluation of Mitochondrial Antioxidants in Oral Potentially Malignant Disorders.</ArticleTitle><Pagination><MedlinePgn>15-27</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2739/kurumemedj.MS661009</ELocationID><Abstract><AbstractText>Various endogenous mitochondria-associated antioxidants protect mitochondria from oxidative stresses such as Superoxide Dismutase 2 (SOD2), Catalase, Glutaredoxin 2 (GLRX2), educed Glutathione (GSH), Glutathione Peroxidase (GPx), and Thioredoxin 2 (TXN2). They protect mitochondria from Reactive Oxygen Species (ROS). Excess ROS causes mitochondrial DNA damage and respiratory chain dysfunction leading to carcinogenesis. In an earlier study we found complex alterations of mitochondrial antioxidants in different stages of oral squamous cell carcinoma. Here, we profiled mitochondrial antioxidants in different oral potentially malignant disorders such as oral leukoplakia (OL), oral lichen planus (OLP), and oral submucous fibrosis (OSMF). Mitochondria was prepared from oral tissues from OL, OLP, and OSMF patients. Biochemical assays and immunoblotting were performed to investigate expression of various mitochondrial antioxidants. Catalase was expressed as Control> OL > OSMF > OLP. GLRX 2 was expressed as OLP> OL >Control >OSMF. GPX1 and GPX4 were expressed as Control >OSMF> OLP > OL. GSH increased in OL and OSMP, but decreased in OLP. SOD2 was expressed as Control >OSMF> OLP > OL. PRX3 was expressed as OL > OLP > OSMF > Control. TXN2 expression was nearly the same in all groups except OL, which showed elevated expression. We conclude that endogenous mitochondria-associated antioxidants show different levels of expressions in various oral potentially malignant disorders.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Banerjee</LastName><ForeName>Sumita</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Oral Pathology and Microbiology, Dental College, Regional Institute of Medical Sciences.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mukherjee</LastName><ForeName>Saikat</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, Manipur University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mitra</LastName><ForeName>Sanjib</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Oral Pathology, Burdwan Dental College and Hospital.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Singhal</LastName><ForeName>Pallav</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>AL-FALAH School of Medical Sciences and Research Center, AL- Falah University.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>05</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>Japan</Country><MedlineTA>Kurume Med J</MedlineTA><NlmUniqueID>2985210R</NlmUniqueID><ISSNLinking>0023-5679</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">mitochondrial antioxidants</Keyword><Keyword MajorTopicYN="N">oral leukoplakia</Keyword><Keyword MajorTopicYN="N">oral lichen planus</Keyword><Keyword MajorTopicYN="N">oral precancerous disorders</Keyword><Keyword MajorTopicYN="N">oral submucous fibrosis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>5</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>5</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>5</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32378537</ArticleId><ArticleId IdType="doi">10.2739/kurumemedj.MS661009</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Banerjee, Sumita" sort="Banerjee, Sumita" uniqKey="Banerjee S" first="Sumita" last="Banerjee">Sumita Banerjee</name><name sortKey="Mitra, Sanjib" sort="Mitra, Sanjib" uniqKey="Mitra S" first="Sanjib" last="Mitra">Sanjib Mitra</name><name sortKey="Mukherjee, Saikat" sort="Mukherjee, Saikat" uniqKey="Mukherjee S" first="Saikat" last="Mukherjee">Saikat Mukherjee</name><name sortKey="Singhal, Pallav" sort="Singhal, Pallav" uniqKey="Singhal P" first="Pallav" last="Singhal">Pallav Singhal</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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